Leading-edge Manufacturing Technology, Immune Modulation Technology, Core Treatment Technology

EC-18 Process and Manufacture Technology
  • Intermediate crystallization Technology, Massive production technology with high purity & yield
  • Technical barriers equal to those of material patents
Immune Modulation Technology

Modulation Technology of Cytokine/Chemokine Release

  • Modulation of IL-4, IL-6 release
  • Modulation of CXCL2/8, CCL26 release

Modulation Technology of Immune Cell Migration and Inflammatory Reaction

  • Modulation of neutrophil/ eosinophil migration
  • Modulation of Transcription factor STAT3, STAT6
Core Treatment Technology
Stage 1
Core Development

Global Phase 2 Clinical Trials

  • Development of First-in-Class RA treatment
  • Chemoradiation therapy induced oral mucositis & ARS through Orphan Drug Designation or Fast Track Designation
Stage 2
Core Development
  • Development of oral RA treatment with superior efficacy against Pfizer’s Xeljanz
  • Development of first-in-class sepsis treatment in the market without competing drug
Stage 3
Mid/Long-term Development
  • Development of treatment for psoriasis, asthma and atopic dermatitis

Mechanism of Action

Mechanism of action of EC-18: ​EC-18 promotes the removal of DAMP and PAMP in a short period of time, thus inhibiting the continuous release of neutrophils from blood vessel, excessive infiltration of immune cells and ​excessive​ release of cytokines in inflammatory tissues and infection site.

Mechanism of Action

Research Papers and Articles

PLAG alleviates chemotherapy-induced thrombocytopenia via promotion of megakaryocyte/erythrocyte progenitor differentiation in mice. Thrombosis Research 161:84-90, 2018.

PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) reduces hepatic injury in concanavalin A-treated mice. Journal of Cellular Biochemistry 119(2):1392-1405, 2018.

PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) ameliorates arthritic joints through reducing neutrophil infiltration mediated by IL-6/STAT3 and MIP-2 activation. Oncotarget 8(57):96636-96648, 2017.

The ameliorating effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on scopolamine-induced memory impairment via acetylcholinesterase inhibition and LTP activation. Behavioural Brain Research 324:58-65.

The Therapeutic Effect of PLAG against Oral Mucositis in Hamster and Mouse Model. Frontiers in Oncology 6:206, 2016

PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) augments the therapeutic effect of pegfilgrastim on gemcitabine-induced neutropenia. Cancer Letters 377: 25-31, 2016

PLAG (1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol) Modulates Eosinophil Chemotaxis by Regulating CCL26 Expression from Epithelial Cells. PLoS One, 11(3):e0151758, 2016

Protective effect of EC-18, a synthetic monoacetyldiglyceride on lung inflammation in a murine model induced by cigarette smoke and lipopolysaccharide. International Immunopharmacology: 30: 62-68, 2016

1-Pamitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol May Reduce Incidence of Gemcitabine-Induced Neutropenia: A Pilot Case-Controlled Study. World Journal of oncology 6(4):410-415, 2015

Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on immune functions in healthy adults in a randomized controlled trial. Immune Network, 15(3):150-60, 2015

1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) Modulates Th2 Immunity through Attenuation of IL-4. Immune Network, 15(2): 100-109, 2015

EC-18, a synthetic monoacetyldiglyceride (1-palmitoyl-2-linoleoyl-3-acetylglycerol), attenuates the asthmatic response in an aluminum hydroxide/ovalbumin-induced model of asthma. International immunopharmacology 21;18(1):116-23, 2014.

Enteral Administration of a Synthetic Monoacetyldiglyceride Improves Survival in a Murine Model of Abdominal Sepsis. Journal of Trauma. 68(1):62-8, 2010

EC-18, a Synthetic Monoacetyldiacylglyceride, Inhibits Hematogenous Metastasis of KIGB-5 Biliary Cancer Cell in Hamster Model. Journal of Korean medical science 24(3):474-80, 2009

Stimulatory effects of monoacetyldiglycerides on hematopoiesis. Biological & Pharmaceutical Bulletin. 27(7):1121-1125, 2004

Purification and structural determination of hematopoietic stem cell-stimulating monoacetyldiglycerides from Cervus nippon (deer antler). 52(7):874-8, 2004​